When draft clinical guidelines or practice parameters are developed by the Joint Task Force on Practice Parameters (JTFPP), ACAAI members have the opportunity to review and comment on the drafts.
ACAAI President James Tracy, DO, FACAAI, would like to invite you to review the draft of 2025 Inborn Errors of Immunity (IEI) Practice Parameter developed by the JTFPP and representatives from the Clinical Immunology Society (CIS). Please take advantage of this opportunity to assist your colleagues in shaping the specialty. The JTFPP will be accepting comments until Thursday, June 26.
The field of IEI has grown substantively over the past decade and continues to expand. Considering the number of publications (developed over time) related to the care of patients with IEI, it would be unwieldy to provide all the available information in a practice parameter. The guiding principle for this practice parameter update was to present the best evidence-based recommendations to support practice, while avoiding being encyclopedic or becoming a textbook.
In this update, several sections utilize tables (with key references) to outline some disease specific recommendations – rather than discussing each one individually in the text. Broadly, the document is divided into diagnostic (1-7) and management (8-14) sections.
New topics of importance to improving the care of patients with IEI are included. Since the last IEI practice parameter in 2015, there have been significant advances in genetic testing, facilitating the identification of novel pathologic monogenetic variants causing IEI. Genetic testing has become widely available, in part due to its decreasing cost.
To provide your suggested revisions and/or comments, please use the official comment form and return your completed form to comments@acaai.org no later than June 26. Only comments submitted on this form will be accepted.
Authors of the document include Drs. Jordan S. Orange, Javier Chinen, Caroline C. Horner, and Lisa J. Kobrynski (editors); and Drs. Mark Ballow, Manish J. Butte, Shanmuganathan Chandrakasan, Ivan K. Chinn, Lisa Forbes Satter, Alexandra F. Freeman, Jennifer R. Heimall, Vijaya Knight, Monica G. Lawrence, Heather K. Lehman, Paul J. Maglione, Elena E. Perez, Kimberley A. Risma, and Jolan E. Walters (section editors).
Workgroup members are Drs. Roshini S. Abraham, Sara Barmettler, Christopher C. Chang, Alice Chan, Karin Chen, Jim Connelly, Lara A. Danziger-Isakov, Maria T. de la Morena, Daniel DiGiacomo, Victoria R. Dimitriades, Morna Dorsey, Daniel E. Dulek, Cullen M. Dutmer, Christopher Dvorak, Jocelyn R. Farmer, Ashley Frazer-Abel, Avni Y. Joshi, Michael D. Keller, Yasmin W. Khan, Maleewan Kitcharoensakkul, Jennifer W. Leiding, Kasiani C. Myers, Vijayalakshmi Nandakumar, Craig D. Platt, Sung-Yun Pai, Niraj C. Patel, Tamara C. Pozos, Jennifer M. Puck, Nicholas L. Rider, Keith A. Sacco, and Kelli W. Williams.
Joint Task Force on Practice Parameters members include Drs. Jay Lieberman and Matt Rank (Co-Chairs), and Drs. Elissa Abrams, Jonathan Bernstein, Anne Ellis, David Golden, Matthew Greenhawt, Kay Horner, Dennis Ledford, Giselle Mosnaim, Marcus Shaker, and Julie Wang.
We look forward to receiving your comments on or before June 26.
