The current issue of Annals of Allergy, Asthma & Immunology focuses on primary immunodeficiencies or inborn errors of immunity (IEIs). The issue has multiple articles and features to help with the diagnosis and treatment of these disorders. The role of the allergist/immunologist in managing these conditions is critical, as we are the primary clinicians for these patients.
The highlight of this issue is the Joint Task Force Practice Parameter on the diagnosis and management of IEIs — the first update in 10 years. You should read the entire parameter for the detailed information, but if you don’t have the time right now, figure 1 of the parameter provides an outstanding summary for the diagnosis and treatment of IEIs. The CME review in this issue by Dr. Charlotte Cunningham-Rundles provides the latest updates on common variable immunodeficiency. In addition, fitting with the theme, there are also two one-page bullet points from the College’s Clinical Immunology and Autoimmune Disease Committee with outstanding highlights on diagnosis of IEIs.
This issue also has other important articles that affect allergy/immunology patients. Dr. Isao Suzaki and colleagues review the remission rate of asthma in patients with chronic rhinosinusitis after treatment with dupilumab. The article examines the concept of a unified airway and the use of therapies to treat both the upper and lower airways together; a concept further expanded in the editorial by Drs. Philipp Suter, Robert Greig, and Brian J. Lipworth.
In the area of treatment of anaphylaxis, Dr. David Golden and colleagues explore the use of sublingual epinephrine, showing comparable pharmacokinetics and dynamics to standard-of-care intramuscular epinephrine. This product is currently under FDA review and might provide another alternative to the approved intramuscular and intranasal devices for rescue epinephrine.
As you read this issue of Annals, we trust the spring pollen season is keeping your practice busy. As always, if you have any comments, please consider sending correspondence to Annals (email us at annals@ACAAI.org). We are always excited to hear how Annals has helped you improve the lives of your patients!
Jonathan Spergel, MD, PHD, FACAAI
Deputy Editor
