The upcoming October issue of the Annals of Allergy, Asthma and Immunology contains a large diversity of information in multiple formats including original articles, reviews, letters and others. Two articles in particular are worthy of mention.
The first is a retrospective study by Dr. Zazzali and colleagues that looked at three of the pivotal studies for the utility of omalizumab for chronic idiopathic urticaria in terms of the effects on accompanying episodes of angioedema. The study looked at results from all three pivotal trials (ASTER I, ASTER II, GLACIAL). Results indicated that higher dose omalizumab (300mg subcutaneously every four weeks) improved the percentage of angioedema free days compared to placebo. Interestingly, most of the episodes of angioedema in all groups was successfully managed with low intensity interventions – taking antihistamines or doing nothing.