From immunoglobulin replacement to anaphylactic reactions in patients with mastocytosis

October 9, 2017

The October issue of the Annals of Allergy, Asthma and Immunology has many articles and features that should be of interest to our readers. We have published on a wide variety that will impact practice.

One such article is written by Mark Ballow, MD, FACAAI, and provides an excellent evidence-based overview of the pragmatic aspects of immunoglobulin replacement. He traces the history of immunoglobulin replacement technology from intramuscular injections to current subcutaneous therapy, and the evolution of dosing strategies including amount and frequency. This is all accomplished using a clinical case and is a must read for all who engage in Ig replacement.

Another article of note is a review article by Maud Hermans, MD and colleagues from the Netherlands who present evidence-based considerations for managing and preventing possible anaphylactic reactions in patients with mastocytosis undergoing invasive and/or radiocontrast-based procedures. The authors describe the incidence based upon procedure type as well as a pragmatic discussion of the theoretical basis for the risk and a rationale for premedication strategy. They point out previously published prophylaxis protocols and finish with practical strategic recommendations. All allergists-immunologists who care for patients with mastocytosis should read and use the information contained in this article.

These and many more information-packed articles are waiting for you in the October issue of the Annals. As always, we welcome your feedback as to how to better serve the needs of our readers through the Annals.

Gailen D. Marshall, Jr., MD, PhD, FACAAI
Editor-in-Chief